A cooperative effort with the UALR Department of Physics is actively pursuing several new techniques of improving ultrasound delivery to targets within various parts of the human body. This is not the usual diagnostic ultrasound technology using 2-10 mHz frequencies; rather, it is centered on lower frequencies ranging from 20 kHz to 1 mHz. This allows much improved range and much improved penetration of energy through various soft tissues and bony structures. The object here is to develop simple application techniques that can deliver therapeutic levels of low-frequency ultrasound within the calvarium, within the base of the skull, and within the neck, for treatment of stroke in conjunction with either tPA or microbubbles or both. It will also have applications in other areas that are easier to reach. These efforts have been performed in both UALR and UAMS laboratories and are ongoing.

One of our related research posters, Microbubble Potentiated Ultrasound as a Method of Stroke Therapy in a Pig Model; Preliminary Findings, is available. A PDF reader is required to view the document.

Research with Dr. Bill Culp
A renowned clinician and academic research scientist, Dr. Culp has received over $2Million in NIH grants in the past 5 years. Dr. Culp directs the radiology research laboratory in the Barton Research Building. In this setting, students, residents and fellows are invited to participate in a wide variety of bench-top and translational projects under the tutelage of an accomplished researcher and clinician. The facility offers high quality imaging equipment with a full complement of support personnel, veterinarians, surgical suites and animal facilities.

William C. Culp, M.D.
Dr. Culp has served as principal investigator on a wide variety of funded research projects. Past research interests have been focused on biliary stents and also small bowel transplantation problems. Other interests include sailboat racing, cruising, and nautical archeology, where he spends considerable time on field trips and serving as a director of the Institute of Nautical Archeology. Dr. Culp also serves on the Board of Directors of CIRREF (Cardiovascular and Interventional Radiology Research and Education Foundation), the research and education arm of the Society of Interventional Radiology, and has devoted a large amount of time and funding to these efforts. Other interests include reviewing manuscripts for three journals and various local community activities